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Human Whole Genome Sequencing

Empowering precision medicine and research by decoding all 3.2 billion base pairs of the human genome with unparalleled accuracy.

What is Human Whole Genome Sequencing (WGS)?

Human Whole Genome Sequencing (WGS) is the process of determining the complete DNA sequence of an individual's genome at a single time.

While targeted panels and exome sequencing (WES) focus only on the protein-coding regions (which make up just 1-2% of the genome), WGS looks at the remaining 98%. This allows researchers and clinicians to discover non-coding mutations, structural variations, and regulatory elements that may be responsible for diseases that other tests miss.

Quick Facts: Yaazh Xenomics WGS

Interrogates 100% of the genome (exons, introns, regulatory regions)

Clinical/Rare disease diagnostics, oncology, and pharmacogenomics

Technology: High-throughput NGS (Illumina / MGI / Nanopore)

Read Depth: Standard 30x depth (Clinical 100x), somatic tumor >100x

Clinical and Research Applications

Rare Disease Diagnostics

WGS is increasingly becoming the go-to test for patients with undiagnosed rare conditions. By analyzing the entire genome, clinicians can pinpoint structural variants and non-coding mutations that standard tests often miss, putting an end to the "diagnostic odyssey".

Precision Oncology

Through Tumor-Normal WGS, researchers can profile the complete mutational landscape of a tumor. It accurately estimates Tumor Mutational Burden (TMB) and identifies structural variants for personalized, targeted cancer therapies.

Population Genomics

For research initiatives, WGS is the best tool for identifying novel variants, understanding genetic diversity across human populations, and discovering the underlying genetic basis of complex, polygenic diseases.

WGS vs. WES vs. Targeted Panels

Comparison

Sequencing Type	Genomic Coverage	Best Used For	Variant Detection Capability
Whole Genome Sequencing (WGS)	~100% (Coding & Non-coding)	Undiagnosed rare diseases, comprehensive oncology	SNVs, Indels, Large SVs, CNVs, structural variants across the entire genome
Whole Exome Sequencing (WES)	~1-2% (Protein-coding only)	Known genetic disorders and standard clinical diagnostics	Primarily SNVs and Indels restricted to exons. Cannot map non-coding elements.
Targeted Gene Panels	< 1% (Specific gene sets)	Testing for specific, known genetic conditions	Highly focused for specific genes to identify well-known variants

Frequently Asked Questions

How long does Whole Genome Sequencing take?

The turnaround time for WGS typically ranges from 4 to 6 weeks, depending on the sequencing depth required (e.g., 30x for clinical cases takes less time than 100x+ for deep oncology profiling) and the complexity of the data analysis.

Is patient genetic data secure with Yaazh Xenomics?

Yes, all genomic data is processed and stored in highly secure, HIPAA and GDPR-compliant IT infrastructures. Patient samples are anonymized with unique barcodes, ensuring absolute privacy and data confidentiality.

What sequencing depth is standard for WGS?

For standard research and population genomics, a mean coverage depth of 30x is the industry standard. For oncology or specific clinical diagnostics, deeper sequencing (100x to 150x) is often required.