NIPT - Non-Invasive Prenatal Testing in India
Advanced Genetic Screening. Analyze cell-free fetal DNA (cffDNA) circulating in maternal blood to screen for common chromosomal aneuploidies and select microdeletions with exceptional sensitivity and specificity.
What is NIPT?
NIPT (Non-Invasive Prenatal Testing) is a screening test performed as early as 10 weeks of pregnancy. It analyzes fragments of fetal DNA present in the mother's blood stream (cell-free fetal DNA) without any risk to the fetus.
Unlike invasive procedures such as amniocentesis or CVS, NIPT is completely safe and carries no risk of miscarriage.
Key Features
Analyzes all 24 chromosomes (1-22, X, Y)
Optional microdeletion screening
Fetal fraction estimation & QC
Proprietary bioinformatics algorithms
Core Aneuploidy Screening
- ✓ Trisomy 21: Down syndrome
- ✓ Trisomy 18: Edwards syndrome
- ✓ Trisomy 13: Patau syndrome
- ✓ Sex Chromosome Aneuploidies: Turner, Klinefelter, Triple X, XYY
Microdeletion Panel
- ✓ 22q11.2 Deletion Syndrome: DiGeorge / Velo-cardio-facial syndrome
- ✓ 1p36 Deletion Syndrome
- ✓ Angelman / Prader-Willi Syndrome: (15q11-q13)
- ✓ Cri-du-chat Syndrome: (5p deletion)
Clinical Performance
Sensitivity (Trisomy 21) >99.9% Specificity (Trisomy 21) >99.5% Positive Predictive Value is significantly higher than traditional serum screening. Low no-call rate due to robust fetal fraction estimation.
NIPT Workflow at Yaazh Xenomics
Pre-Test Counseling
Detailed discussion of test limitations, sensitivity, and clinical implications with a genetic counselor.
Blood Collection
10 ml peripheral maternal blood in specialized Streck tubes (from 10 weeks gestation).
Extraction & Prep
Cell-Free DNA extraction and robust library preparation for targeted NGS.
Sequencing
Deep targeted Next-Generation Sequencing of selected chromosomal regions.
Bioinformatics
Proprietary algorithms for fetal fraction estimation and aneuploidy detection.
Clinical Reporting
Clear, easy-to-understand report delivery with post-test genetic counselor support.
Who Should Consider NIPT?
- All pregnant women (as a primary screening test)
- Women with advanced maternal age (>35 years)
- High-risk pregnancies identified by first-trimester combined screening
- History of previous chromosomal abnormality
- Parents carrying balanced translocation carriers
Advantages of Yaazh Xenomics NIPT
Non-invasive - zero risk to mother or fetus:
Early detection - from 10 weeks of gestation:
Higher accuracy than traditional first/second-trimester screening:
Advanced bioinformatics with low false positive rate:
Fast turnaround time (7-10 working days):
Affordable pricing with transparent packages: